Why is Thor’s Hammer, Molnupiravir, Considered a 4th Line Option for COVID-19?

Two novel oral antiviral agents were granted emergency use authorization (EUA) by the U.S. Food and Drug Administration (FDA) for the treatment of mild to moderate COVID-19 in late December 2021. Although it is named after Thor’s hammer, Mjölnir, molnupiravir was given a last place (4^th line) recommendation by the National Institutes of Health (NIH) COVID-19 Treatment Guideline Panel.  What gives?

Guest Authors: Amanda Applegate, PharmD, BCACP and Mary Beth Dameron, PharmD, BCACP

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