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Preserving hope for patients with Heart Failure with Preserved Ejection Fraction (HFpEF)?

Although guideline-directed medical therapy substantially improves morbidity and mortality in patients with heart failure with reduced ejection fraction (HFrEF), treatments that clearly improve outcomes in those with HF and an EF >40% remain elusive. Unfortunately, the incidence and prevalence of HF are expected to substantially increase in the coming decades.  More evidence and effective treatments for those with HF with preserved ejection fraction are clearly needed.  Enter the EMPEROR-Preserved trial.

Guest Authors:  Gabrielle Givens, PharmD, BCPS and Robert Parker, PharmD

Music by Good Talk

Top Ten Things Every Clinician Should Know about Continuous Glucose Monitors (CGM)

Continuous glucose monitors (CGMs) are now commonplace, and every clinician should know the basics about who can benefit from CGM use and how to address common questions and problems. 

Authors:  Brianna Patacini, PharmD, BCACP, CDCES and Dawn Fuke, PharmD, BCPS

Special Guest: Jennifer Trujillo, PharmD, BCPS, CDCES, BC-ADM

Music by Good Talk

Spice Up Your Sleep Life with Saffron

Every day, millions suffer from poor sleep that disrupts their lives, and long-term sleep disorders can cause attention deficits, mood disorders, anxiety, and depression. Several prescription treatment options for sleep are available but they often have undesirable side effects and can lead to tolerance and dependency. Thus, a natural product that has been documented to improve sleep with minimal adverse events may be a better choice.

Guest Authors:  Alyssa Korman, PharmD and Nicole Slater, PharmD, BCACP

Music by Good Talk

Will a Dual GIP/GLP-1 Receptor Agonist SURPASS the Crowd?

There are now over 30 unique therapeutic entities (and countless different products!) to treat hyperglycemia in patients with type 2 diabetes mellitus (T2DM).  While the glucagon-like peptide-1 (GLP-1) receptor agonists improve glycemic control, renal, and cardiovascular outcomes and induce significant weight loss, drugs that target more than one incretin hormone may have even greater therapeutic benefits.

Guest Authors: Nadila Faridi, PharmD and Kathleen Pincus, PharmD, BCPS, BCACP

Special Guest: Diana Isaacs, PharmD, BCPS, BCACP, BC-ADM, CDCES

Music by Good Talk

Cut It Out! Removing EHR Allergy Warnings to Improve Antimicrobial Stewardship

WARNING: Patient has a penicillin allergy! Do you want to continue with this cephalexin order?

Although these warnings are commonplace, immunologic cross-reactivity between penicillins and cephalosporins is uncommon. When B-lactams are indicated as first-line therapy for therapy, cephalosporins are often avoided if the patient has a penicillin allergy listed. Would the removal of EHR warnings about potential penicillin allergies when cephalosporins are ordered be helpful or harmful? 

Guest Authors:  Brian Wenger, PharmD and Nora Sharaya, PharmD, BCPS, BCACP, BC-ADM

Music by Good Talk

What’s the Right Dose of Aspirin in Patients with Heart Disease?

There is no consensus regarding the preferred dosage of aspirin in patients with atherosclerotic cardiovascular disease (ASCVD) and this has led to variability in prescribing patterns. This is likely due to the lack of head-to-head trials evaluating different aspirin doses and data weighing the clinical benefits and adverse effects experienced with aspirin. Until now?

Guest Authors: Ivy Nwogu, PharmD and Megan Supple, PharmD, BCACP, CPP

Music by Good Talk

Bursting the Steroid Bubble: Short-term Use Has Its Consequences

Short courses of corticosteroids, also known as “steroid bursts,” are frequently utilized in both pediatrics and adults; however, evidence supporting the safety of these bursts is lacking. Long-term use of oral corticosteroids is associated with a number of serious adverse effects.  New evidence suggests that a steroid burst is not risk-free.

Guest Authors:  Irene Ruiz, PharmD and Kristine A. Parbuoni, PharmD, BCPPS

Music by Good Talk

Guiding Antiplatelet Therapy: Is a Personalized Approach Worth It?

Variability in clopidogrel pharmacokinetics among patients has been appreciated for years and this results in inconsistent effects on platelet inhibition and poor outcomes. Multiple strategies to personalize antiplatelet therapy intended to balance the risks and benefits of therapy have been tested. A recent systematic review and meta-analysis attempts to answer the question: Is a personalized approach worth it?

Guest Authors:  Kiana R. Green, PharmD and Augustus (Rob) Hough, PharmD, BCPS, BCCP

Music by Good Talk

Psilocybin for Depression: Is it Worth the Trip?

Although there are numerous medications available to treat major depressive disorder, not all patients respond, and some experience intolerable side effects. Thus, we need to find and develop new treatment options. There has been considerable interest in psychedelic compounds that may have antidepressant activity. Recent research using psychedelics for mental health conditions has made news headlines, but most health professionals have only a vague awareness about psilocybin and its potential role.

Guest Authors:  Brittany L. Parmentier, PharmD, MPH, BCPS, BCPP and Andria F. Church, PharmD, BCPS, BCPP

Music by Good Talk

Up the Creek Without a Paddle? Look to Your Pharmacist to Bridge-It

Nearly half of all pregnancies are unintended and a high percentage of unwanted pregnancies lead to an abortion. Reducing the number of unintended pregnancies and increasing the use of effective birth control are two public health priorities. Could the implementation of pharmacist contraception prescribing combined with EC on the same day help “bridge the gap?”

Guest Authors:  Ashley H. Meredith, PharmD, MPH, BCACP, BCPS, CDCES and Veronica P. Vernon, PharmD, BCPS, BCACP, NCMP

Music by Good Talk

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