Fixed Dose or Treat-to-Target: Does LODESTAR Guide Us on Statin Management?

There has been a long-standing debate about the optimal approach to statin use, including whether we should initiate therapy using a “fixed-dose”, high-potency statin, or whether we should “start low and go slow” by titrating the dose to a specific LDL-C target. The LODESTAR study was designed to determine if treating LDL-C to a target level produces similar cardiovascular outcomes when compared to a fixed-dose approach.

Guest Authors: Dawn Fuke, PharmD, BCPS and Catherine Behret, PharmD, BCACP

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