Could a DOAC Replace Warfarin to Treat the Thrombotic Antiphospholipid Syndrome?

The thrombotic antiphospholipid syndrome (TAPS) is associated with atypical thromboembolic events and/or recurrent pregnancy loss. Patients with TAPS are at very high risk of recurrent thrombotic events and require indefinite therapy.  Warfarin therapy is very challenging to manage in this patient population and requires frequent monitoring.  Thus a direct oral anticoagulant would be a welcomed alternative to warfarin by many patients with TAPS.  But are they effective?

Guest Authors: Leslie Walters, PharmD, BCACP  and Jennifer Carie, PharmD, BCACP, BC-ADM

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