Chronic obstructive pulmonary disease (COPD) exacerbations contribute to mortality, disease progression, worsening quality of life, and increased health care costs. Respiratory tract infections are a common cause of COPD exacerbations. While prophylactic antibiotics may play a role, vitamin D supplementation is an attractive option by stimulating innate and adaptive immune responses. Although severe vitamin D deficiency (25(OH)D <10 ng/mL) has been associated with more frequent exacerbations and hospitalizations in patients with COPD, it is unclear if supplementation actually reduces exacerbation frequency. A recent meta-analysis provides some data regarding the potential benefits of vitamin D supplement to prevent COPD exacerbations.
Guest Authors: Jennifer Clements, PharmD, BCPS, BCACP and Lisa Gibbs, PharmD
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