Can We KEEP Perimenopausal Women Sexually Satisfied?

Can We KEEP Perimenopausal Women Sexually Satisfied?

March 16, 2018

Female sexual dysfunction (FSD) effects women of all ages but is common among perimenopausal / postmenopausal women and may be related to a reduction in circulating estrogen.  Oral estrogens increase sex hormone-binding globulin (SHBG) which lowers available free testosterone and thus may negatively impact sexual function.Transdermal estrogens are typically preferred because they lack a high first-pass effect and are not associated with risk of thromboembolic events. However, additional research – directly comparing oral and transdermal preparations – was needed.  An ancillary study of the Kronos Early Estrogen Prevention Study (KEEPS) did just that - examined the impact of oral and transdermal estrogens on sexual functioning.

Guest Authors:  Stefanie C. Nigro, PharmD, BCACP and Christine Dimanculangan, Pharm.D.

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